Patent · US Expired

Peptide plasminogen activators

US5439679A · kind A · utility

1Cited by

6References

13Claims

0Family size

Assignees

Chiron Corporation · US
Behringwerke Aktiengesellschaft · DE

Inventors

Ernest-Guenter Afting · Marburg, DE
Eric-Paul Paques · Marburg, DE
Nancy L. Haigwood · Oakland, US
Guy Mullenbach · Oakland, US

Key dates

Filing date	Mar 10, 1994
Grant date	Aug 8, 1995
Priority date	—
Expiry date	Mar 10, 2014

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21069
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibition by plasminogen activator inhibitor, fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying one or more loci by deletions or substitutions. One or both of the N- or C-termini may be modified. The plasmids designated 1, 2 and 3 were deposited at the A.T.C.C. on Dec. 20, 1985 and given A.T.C.C. designations 40214, 40215 and 40216, respectively.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.