[ALA IL-8].sub.77 and [SER IL-8].sub.72 as Leukocyte adhesion inhibitors
US5451399A · kind A · utility
24Cited by
3References
3Claims
0Family size
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Key dates
| Filing date | Oct 19, 1992 |
| Grant date | Sep 19, 1995 |
| Priority date | — |
| Expiry date | Oct 19, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel polypeptide [Ala IL-8].sub.77 is provided which is a potent modulator of neutrophil functions. The polypeptide factor and related compositions find use as anti-inflammatory agents and as therapeutics for clinical indications in which damage to vascular endothelium and other tissues occurs. The amino acid and nucleotide sequence of the factor and methods for its purification, recombinant production and pharmaceutical use are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.