Eukaryotic transcription protein; host cell factor
US5453362A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Apr 12, 1993 |
| Grant date | Sep 26, 1995 |
| Priority date | — |
| Expiry date | Apr 12, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/827
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Host Cell Factor (HCF), a eukaryotic cellular protein involved in transcription, nucleic acids encoding HCF, and methods of using HCF and HCF-encoding nucleic acids are provided. HCF activity is disclosed to comprise a collection of polypeptides encoded by a structural gene encoding a parent protein of 2039 amino acids. HCF-specific binding compounds are disclose including antibodies to HCF epitopes. Because HCF is required for the transcription of a number of vital genes such as the immediate early genes of Herpes Simplex Virus, the invention provides HCF-based methods for screening chemical libraries for regulators of viral transcription. Such regulators are used in the treatment of viral infections by modulating the transcription of certain viral genes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.