Michellamine antiviral agents, compositions, and treatment methods

US5455251A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Michael R. Boyd · Mobile, US
• John H. Cardellina, II · Fort Detrick, US
• Kirk P. Manfredi · Cedar Falls, US
• John W. Blunt · Christchurch, NZ
• Lewis K. Pannell · Mobile, US
• James B. McMahon · Frederick, US
• Robert J. Gulakowski · Frederick, US
• Gordon M. Cragg · Bethesda, US
• Gerhard Bringmann · Würzburg, DE
• Duncan Thomas · Corvallis, US
• Johnson Jato · Randburg, ZA

Key dates

• Filing date: Apr 19, 1993
• Grant date: Oct 3, 1995
• Expiry date: Apr 19, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.