Apparatus and processes for the large scale generation and transfer of diazomethane

US5459243A · kind A · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Oscar L. Acevedo · San Diego, US
• Bruce Ross · Carlsbad, US
• Robert S. Andrews · Saint Peters, US
• Robert H. Springer · Wyckoff, US
• Phillip Dan Cook · Carlsbad, US

Key dates

• Filing date: Mar 10, 1994
• Grant date: Oct 17, 1995
• Expiry date: Mar 10, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C245/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

For large scale preparation of pyrimidine ribonucleosides, the intermediate 2-O-methyl-(or ethyl)-1,3,5-tri-O-benzoyl-.alpha.-D-ribose can be prepared using a diazomethane (or diazoethane) reaction that is controlled via an inert solvent transferring system. This transfer system allows for large scale preparations of the pyrimidine ribonucleosides.