14-halo-camptothecins
US5459269A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 2, 1994 |
| Grant date | Oct 17, 1995 |
| Priority date | — |
| Expiry date | Dec 2, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of making racemic DE ring intermediates for the synthesis of camptothecin and camptothecin analogs employing novel intermediates of Formula (XX) and (XXI): ##STR1## wherein R.sub.20 is loweralkyl, R is loweralkyl, Y is H or halogen, and R.sub.21 is loweralkoxy; as precursors to the DE ring intermediate. The present invention also provides a camptothecin analog of Formula (I-A): ##STR2## wherein: Hal is a halogen; PA1 and the remainder of the variables are as defined in the specification. Additionally, other novel compounds useful in the preparation of the compounds of Formula (I-A) and methods of producing compounds of (I-A) are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.