Inventor · Raleigh, NC, US

Daniel L. Comins

43Patents
9h-index
14Co-inventors
72Inventor score

Filing activity: Dec 20, 1990 → Sep 2, 2022

Most-cited inventions

PatentTitleAreaCited byStatus
US5162532A Intermediates and method of making camptothecin and camptothecin analogs Chemistry; Metallurgy 37 Expired
US6995265B2 Synthesis of nicotine derivatives from nicotine Chemistry; Metallurgy 19 Expired
US5191082A Camptothecin intermediate and method of making camptothecin intermediates Chemistry; Metallurgy 16 Expired
US5243050A Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs Chemistry; Metallurgy 15 Expired
US5247089A Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs Chemistry; Metallurgy 15 Expired
US5212317A Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs Chemistry; Metallurgy 14 Expired
US5321140A Pyridinecarboxaldehyde D-ring intermediates useful for the synthesis of camptothecin and camptothecin analogs Chemistry; Metallurgy 11 Expired
US5200524A Camptothecin intermediates and method of making same Chemistry; Metallurgy 11 Expired
US6063923A Preparation of a camptothecin derivative by intramolecular cyclisation Chemistry; Metallurgy 11 Expired
US5258516A Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs Chemistry; Metallurgy 8 Expired
US5459269A 14-halo-camptothecins Chemistry; Metallurgy 6 Expired
US5315007A Process for making DE ring intermediates for the synthesis of camptothecin and camptothecin analogs Chemistry; Metallurgy 6 Expired
US5264579A D ring intermediates for the synthesis of camptothecin and camptothecin analogs Chemistry; Metallurgy 6 Expired
US5254690A Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs Electricity 6 Expired
US5475108A Camptothecin intermediates and method of making camptothecin and comptothecin analogs Chemistry; Metallurgy 5 Expired
US7067672B2 Regioselective halogenation of nicotine and substituted nicotines Chemistry; Metallurgy 5 Expired
US5262571A Cycloalkyl-based chiral auxiliaries and method making the same Chemistry; Metallurgy 4 Expired
US7132545B2 Synthesis of nicotine derivatives from nicotine Chemistry; Metallurgy 4 Expired
US7501520B2 Regioselective halogenation of nicotine and substituted nicotines Chemistry; Metallurgy 3 Active
US5428166A Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs Chemistry; Metallurgy 3 Expired
US5395939A Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs Chemistry; Metallurgy 3 Expired
US7179917B2 Regioselective halogenation of nicotine and substituted nicotines Chemistry; Metallurgy 2 Expired
US7304160B2 Regiospecific synthesis of nicotine derivatives Chemistry; Metallurgy 2 Active
US7112678B2 Regiospecific synthesis of nicotine derivatives Chemistry; Metallurgy 2 Expired
US5478943A Method of making intermediates for camptothecin and its analogs Chemistry; Metallurgy 1 Expired

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.