Expression of PACE in host cells and methods of use thereof
US5460950A · kind A · utility
176Cited by
11References
60Claims
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Key dates
| Filing date | May 20, 1992 |
| Grant date | Oct 24, 1995 |
| Priority date | — |
| Expiry date | May 20, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/755
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These compositions and methods utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.