Method for evaluating immunogenicity
US5470560A · kind A · utility
18Cited by
2References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 4, 1994 |
| Grant date | Nov 28, 1995 |
| Priority date | — |
| Expiry date | Feb 4, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Biological effects of agents for diagnostic or therapeutic use are evaluated by administration of the agents to transgenic animals which are transformed with heterologous DNA and which are immune tolerant to the expression product of the heterologous DNA. In a further embodiment, preparations that are immunogenic in the transgenic animal model are purified by reverse immunoaffinity chromatography on antibody obtained from responding transgenic animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.