Ligands of thrombin
US5476766A · kind A · utility
125Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 6, 1992 |
| Grant date | Dec 19, 1995 |
| Priority date | — |
| Expiry date | Nov 6, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/976
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are described for the identification of nuclei acid ligand solutions to thrombin. The present invention utilizes the SELEX (Systematic Evolution of Ligands for EXponential enrichment) method for identifying and preparing RNA ligands to thrombin. Further included in the present invention are modified nucleotide sequences based on the sequences of the RNA ligands identified. The modified RNA ligands to thrombin exhibit increased in vivo stability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.