Process for antibody combining site-catalyzed SYN elimination in the formation of a CIS olefin
US5478728A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 25, 1994 |
| Grant date | Dec 26, 1995 |
| Priority date | — |
| Expiry date | Aug 25, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is disclosed by which a substrate is catalytically converted to a cis olefin via a syn elimination reaction. The catalyst is a monoclonal antibody or paratope-containing molecule that binds to the substrate as well as to a bicyclo[2.2.1]heptane or bicylo[2.2.2]octane compound that is an analogue to the substrate having its bulky substituents in eclipsed positions. The chemical reaction is carried out in an aqueous medium. The catalyst molecules and hybridoma cells that secrete those molecules are also contemplated, as is a process for using cyclopentadiene or cyclohexadiene to prepare a hapten used to induce production of the catalyst molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.