Process for the preparation of DNA gyrase inhibitors
US5486466A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 1994 |
| Grant date | Jan 23, 1996 |
| Priority date | — |
| Expiry date | Nov 14, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/886
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bicyclic derivatives of the general formula ##STR1## wherein X.sup.1 is --S-- or --SO--; PA1 X.sup.2 is --CO-- or --CS--; PA1 R.sup.1 is hydrogen, halogen or lower alkyl optionally substituted by halogen or lower alkoxy; PA1 R.sup.2 and R.sup.3 are each independently hydrogen, lower alkyl, halogen, amino, lower alkylamino, di-lower alkylamino, acylamino, lower alkexy, lower alkoxymethoxy or a group OR.sup.4 ; PA1 R.sup.4 is hydrogen or an easily hydrolyzable group; PA1 R.sup.5 is hydrogen, optionally esterified carboxy or amidated (thio)carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted acyl or heterocyclyl; PA1 R.sup.6 and R.sup.7a are each independently hydrogen or lower alkyl; PA1 R.sup.7b is hydrogen, optionally substituted hydroxy, --NR--A or --N.dbd.B, in which R is hydrogen or lower alkyl, A is hydrogen, optionally substituted alkyl, lower cycloalkyl, iminoyl, (thio)acyl, esterified carboxy or amidated (thio)carboxy and B is lower alkylidene; PA1 R.sup.7a and R.sup.7b together represent oxo, lower alkoxycarbonylmethylidene or optionally substituted hydroxyimino; and PA1 R.sup.8 is hydrogen, optionally substituted alkyl, optionally e…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.