Association peptides

US5491074A · kind A · utility

Assignee

• Affymax Technologies N.V. · NL

Inventors

• Lois Aldwin · San Mateo, US
• Mark Madden · San Diego, US
• Willem P. C. Stemmer · Los Gatos, US

Key dates

• Filing date: May 24, 1993
• Grant date: Feb 13, 1996
• Expiry date: May 24, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/42
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Peptides that form lightly associated homodimers can be used to form dimers and multimers of other molecules and molecular motifs of interest. These association peptides can dimerize regardless of whether motifs are added to the amino-terminus of the peptide, or the carboxy terminus of the peptide, although additions to the carboxy-terminus of the association peptides require the presence of certain acidic residues.