Acid stable purine dideoxynucleosides

US5495010A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Victor E. Marquez · Gaithersburg, US
• John S. Driscoll · Rockville, US
• Christopher K. Tseng · Burtonsville, US
• James A. Kelley · Silver Spring, US
• David G. Johns · Bethesda, US
• Hiroaki Mitsuya · Rockville, US

Key dates

• Filing date: Sep 19, 1991
• Grant date: Feb 27, 1996
• Expiry date: Sep 19, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Purine nucleosides active against human immunodeficiency virus which are substituted at the 2'-position by a strong electronegative group such as fluorine are stable in an acid environment and thus can be used for oral administration.