Peptides and antibodies that inhibit platelet adhesion
US5498499A · kind A · utility
5Cited by
5References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 15, 1992 |
| Grant date | Mar 12, 1996 |
| Priority date | — |
| Expiry date | May 15, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/811
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPIIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.