Serine protease and uses thereof

US5500344A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Thomas Joseph Sayers · Boonsboro, US
• Mark Smyth · Melbourne, AU
• Theresa A. Wiltrout · Frederick, US
• James C. Powers · Atlanta, US
• Raymond Sowder · Frederick, US
• Louis E. Henderson · Mount Airy, US

Key dates

• Filing date: Dec 3, 1992
• Grant date: Mar 19, 1996
• Expiry date: Dec 3, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/6467
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides a purified and isolated nucleic acid molecule encoding serine protease (Met-ase) having Met-ase activity but not Asp-ase activity and a molecular weight of about 30,000 daltons on SDS PAGE under reducing and non-reducing conditions. The present invention also provides a vector comprising this nucleic acid molecule, a prokaryotic or eukaryotic host cell stably transformed or transfected with the vector, as well as a method for detecting this nucleic acid in a sample.