Patent · US Expired

Peptide plasminogen activators

US5501853A · kind A · utility

4Cited by

6References

15Claims

0Family size

Assignees

Chiron Corporation · US
Behringwerke Aktiengesellschaft · DE

Inventors

Nancy L. Haigwood · Oakland, US
Ernest-Guenter Afting · Marburg, DE
Guy Mullenbach · Oakland, US
Eric-Paul Paques · Marburg, DE

Key dates

Filing date	Dec 22, 1986
Grant date	Mar 26, 1996
Priority date	—
Expiry date	Dec 22, 2006

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21069
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibition by plasminogen activator inhibitor, fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying one or more loci by deletions or substitutions. One or both of the N- or C-termini may be modified.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.