Pulsed low frequency EPR spectrometer and imager

US5502386A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• John Bourg · Bethesda, US
• James B. Mitchell · Damascus, US
• Mark Mirotznik · Silver Spring, US
• Bradley Roth · Kensington, US
• Sankaran Subramanian · Kothagudem, IN
• Murali K. Cherukuri · North Potomac, US
• Paul G. Zablocky · Shrewsbury, US
• Thomas J. Pohida · Monrovia, US
• Paul D. Smith · Redondo Beach, US
• Walter S. Friauf · Bethesda, US
• Rolf G. Tschudin · Kensington, US

Key dates

• Filing date: Nov 15, 1994
• Grant date: Mar 26, 1996
• Expiry date: Nov 15, 2014

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/60
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An EPR imager and spectrometer includes pulse generating system for generating broadband pulses having an RF carrier frequency that is not highly absorbed by biological samples. The pulse generating system includes up and down chirp convertors for frequency modulating a carrier frequency pulse and compressing the frequency modulated pulse to form a broadband excitation pulse of high energy. Such a machine could form the basis of a clinical imaging device capable of high sensitivity to free radical species in human patients.