Recombinant mutants for inducing specific immune responses
US5503829A · kind A · utility
17Cited by
1References
9Claims
0Family size
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Key dates
| Filing date | Nov 7, 1994 |
| Grant date | Apr 2, 1996 |
| Priority date | — |
| Expiry date | Nov 7, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A recombinant plasmid comprises the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella, adenylate cyclase in a transformed host cell. A recombinant DNA molecule can comprise the Bordetella cyaA gene containing at least one insertion of a heterologous DNA sequence at at least one permissive site. In addition, a recombinant Bordetella adenylate cyclase comprises a heterologous epitope at a permissive site. Methods of inducing a specific B cell, helper T cell, and CTL cell immune response are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.