Patent · US Expired

Oligonucleotides with substantially chirally pure phosphorothioate linkages

US5506212A · kind A · utility

84Cited by

0References

6Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Glenn Hoke · Mount Airy, US
Phillip Dan Cook · Carlsbad, US

Key dates

Filing date	Aug 29, 1994
Grant date	Apr 9, 1996
Priority date	—
Expiry date	Aug 29, 2014

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3533
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Sequence specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic synthesis from nucleoside 5'-O-(1-thiotriphosphates).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.