P450db1 clones for identifying humans with genetic defect in drug metabolism

US5508199A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Frank J. Gonzalez · Bethesda, US
• James Hardwick · North Chicago, US
• Harry V. Gelboin · Bethesda, US
• Urs Meyer · Oberwil, CH

Key dates

• Filing date: May 13, 1994
• Grant date: Apr 16, 1996
• Expiry date: May 13, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A cloned cDNA encoding debrisoquine 4-hydroxylase gene and a probe for identifying humans having a genetic defect in the metabolism of a certain class of drugs of which debrisoquine is a model, have been prepared. Testing of new drugs and of humans by a simple assay has also been described.