Bis-acridone chemotherapeutic derivatives

US5508289A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Christopher J. Michejda · North Potomac, US
• Wieslaw M. Cholody · Frederick, US
• Lidia Hernandez · Gaithersburg, US

Key dates

• Filing date: Mar 14, 1994
• Grant date: Apr 16, 1996
• Expiry date: Mar 14, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D219/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides an anticancer compound having the structure: ##STR1## wherein R is --H, --CH.sub.3, or --C.sub.2 H.sub.5 ; R1 and R2 are independently --H, --OH, --NH.sub.2, --OCH.sub.3, --C(CH.sub.3).sub.3, or a halogen atom; n is 2 to 6; X and X' are independently --N or --NO.sub.2 ; Y and Y' are independently --N, --CH, or --H; and the double-slash represents a double bond or no bond; such that when X or X' is --N, Y or Y' is --CH or --N, and the double-slash is a double bond, and when X or X' is --NO.sub.2, Y or Y' is --H, and the double-slash is no bond. The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier.