Carbocation scavenging during oligonucleotide synthesis
US5510476A · kind A · utility
40Cited by
12References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 7, 1994 |
| Grant date | Apr 23, 1996 |
| Priority date | — |
| Expiry date | Jul 7, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.