Variants of plasminogen activators and processes for their production
US5520911A · kind A · utility
9Cited by
16References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1994 |
| Grant date | May 28, 1996 |
| Priority date | — |
| Expiry date | Dec 13, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21069
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.