Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them

US5521177A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Uwe Ries · Biberach an der Riß, DE
• Norbert Hauel · Schemmerhofen, DE
• Jacques van Meel · Mittelbiberach, DE
• Wolfgang Wienen · Äpfingen, DE
• Michael Entzeroth · Warthausen, DE

Key dates

• Filing date: Oct 4, 1993
• Grant date: May 28, 1996
• Expiry date: Oct 4, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to benzimidazoles of general formula ##STR1## Exemplary compounds are: (a) 4'-[[2-Ethyl-4-methyl-6-[(2-dimethylamino-3,4-dioxo-1-cyclobuten-1-yl)amin o]-1H-benzimidazol-1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl, PA1 (b) 4'-[[2-n-Propyl-4-methyl-6-(2-cyano-3,3-dimethyl-guanidino)-1H-benzimidazo l-1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl, PA1 (c) 4'-[[2-n-Propyl-4-methyl-6-(2,2-dicyano-1-dimethylamino-etheneamino)-1H-be nzimidazol -1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl, PA1 (d) 4'-[[2-n-Propyl-4-methyl-6-(1-morpholino-2-nitro-etheneamino)-1H-benzimida zol -1 -yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl, and PA1 (e) 4'-[[2-n-Propyl-4-methyl-6-(1,1-dimethylamino-2-nitro-etheneamino)-1H-benz imidazol -1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl. The new compounds are angiotensin-antagonists.