Conjugates for introducing nucleic acid into higher eucaryotic cells

US5521291A · kind A · utility

Assignees

• Boehringer Ingelheim International GmbH · DE
• Genentech, Inc. · US
• The University of North Carolina at Chapel Hill · US

Inventors

• David T. Curiel · Birmingham, US
• Ping Hu · Shanghai, CN
• Max L. Birnstiel · Wien, AT
• Matthew Cotten · Wien, AT
• Ernst-Werner Wagner · Langenzersdorf, AT

Key dates

• Filing date: Dec 15, 1993
• Grant date: May 28, 1996
• Expiry date: Dec 15, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/081
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conjugates in which a virus is bound via an antibody to a substance having an affinity for nucleic acid, for transporting gene constructs into higher eucaryotic cells. Complexes of the conjugates and nucleic acid are internalized in the cell, whilst the virus as part of the complex brings about the internalization and the release of the contents of the endosomes, in which the complexes are located after entering the cell. Pharmaceutical preparations in which the nucleic acid is a therapeutically active gene construct, particularly for use in gene therapy.