Trisubstituted cycloalkane derivatives and process for the preparation thereof
US5523303A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 11, 1994 |
| Grant date | Jun 4, 1996 |
| Priority date | — |
| Expiry date | Apr 11, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel, pharmaceutically active trisubstituted cycloalkane derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The invention also encompasses the use of the said cycloalkane derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The compounds according to the invention are characterized by the general formula (I), ##STR1## wherein R represents hydrogen, C.sub.1-4 alkyl or hydroxyl, PA1 R.sup.1 stands for C.sub.1-12 alkyl, PA1 R.sup.2 and R.sup.3 each represents hydrogen, C.sub.1-12 alkyl or C.sub.2-12 alkenyl, or PA1 R.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a 4- to 7-membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which latter may carry a phenyl, benzyl or C.sub.1-4 alkyl substituent, PA1 R.sup.4 and R.sup.5 each stands for hydrogen, halogen or C.sub.1-4 alkoxy, or together represent a 3,4-methylenedioxy group, PA1 n is an integer from 2 to 5, PA1 A represents a valency bond or a --CH.sub.2 -- group. The compounds exert a valuable antiulcer effect, so they can be used …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.