Inhibitors of human immunodeficiency virus
US5523389A · kind A · utility
53Cited by
2References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 28, 1993 |
| Grant date | Jun 4, 1996 |
| Priority date | — |
| Expiry date | Sep 28, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/346
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The phosphorothioate oligonucleotide T.sub.2 G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible 8-nucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosinequartet (G-quartet) structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The G-quartet structure binds to the HIV envelope protein gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.