Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same

US5525357A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Larry K. Keefer · Bethesda, US
• Joseph A. Hrabie · Frederick, US
• Joseph E. Saavedra · Thurmont, US

Key dates

• Filing date: Sep 14, 1993
• Grant date: Jun 11, 1996
• Expiry date: Sep 14, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F8/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.