In vitro activation of cytotoxic t-cells using insect cells expressing human class I MHC and .beta.2-microglobulin
US5529921A · kind A · utility
27Cited by
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12Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 10, 1994 |
| Grant date | Jun 25, 1996 |
| Priority date | — |
| Expiry date | Mar 10, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/75
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a rational, elegant means of producing, loading and using Class I molecules to specifically activate CD8 cells in vitro, and their therapeutic applications in the treatment of a variety of conditions, including cancer, tumors or neoplasias, as well as viral, retroviral, autoimmune, and autoimmune-type diseases. The present invention also relates to vectors, cell lines, recombinant DNA molecules encoding human .beta.2 microglobulin or Class I MHC molecules in soluble and insoluble form, and methods of producing same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.