Substituted 2,4-imidazolidinediones

US5530016A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Thomas Kramer · Wuppertal, DE
• Rudolf Hanko · Düsseldorf, DE
• Jurgen Dressel · Radevormwald, DE
• Peter Fey · Wuppertal, DE
• Walter Hubsch · Wuppertal, DE
• Ulrich Muller · Wuppertal, DE
• Matthias Muller-Gliemann · Haan, DE
• Martin Beuck · Milford, US
• Hilmar Bischoff · Wuppertal, DE
• Stefan Wohlfeil · Hilden, DE
• Dirk Denzer · Wuppertal, DE
• Stanislav Kazda · Wuppertal, DE
• Johannes-Peter Stasch · Wuppertal, DE
• Andreas Knorr · Erkrath, DE
• Siegfried Zaiss · Wuppertal, DE

Key dates

• Filing date: May 18, 1994
• Grant date: Jun 25, 1996
• Expiry date: May 18, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.