Anti-HIV protein, TAP 29, from tricosanthes, DNA coding therefor and therapeutic uses thereof

US5532214A · kind A · utility

Assignees

• NEW YORK UNIVERSITY · US
• American BioScience, Inc. · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Sylvia Lee-Huang · New York, US
• Philip L. Huang · Boston, US
• Hao-chia Chen · Potomac, US
• Hsiang-Fu Kung · Verona, US
• Peter Huang · New York, US
• Henry Huang · New York, US
• Paul Huang · Boston, US

Key dates

• Filing date: Jul 14, 1994
• Grant date: Jul 2, 1996
• Expiry date: Jul 14, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A new protein, termed TAP 29, obtainable from the root tuber of the plant Trichosanthes kirilowii or produced by recombinant means is useful for treating HIV infections or tumors. In treating HIV infections, the protein is administered alone or in conjunction with conventional AIDS therapies. Also provided are processes for purifying the protein, DNA sequences encoding the protein, hosts expressing the protein, recombinant DNA methods for expressing the protein, and antibodies specific for the protein.