Cardiac hypertrophy factor and uses therefor

US5534615A · kind A · utility

Assignees

• Genentech, Inc. · US
• The Regents of the University of California · US

Inventors

• Joffre B. Baker · Montara, US
• Kenneth R. Chien · Cambridge, US
• Kathleen King · Pacifica, US
• Diane Pennice · Burlingame, US
• William I. Wood · Hillsborough, US

Key dates

• Filing date: Apr 25, 1994
• Grant date: Jul 9, 1996
• Expiry date: Apr 25, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/14
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

. SUPPL):326, (1992). Sen et al., "Myotrophin: Purification of a Novel Peptide from Spontaneously Hypertensive Rat Heart That Influences Myocardial Growth", J. Biol. Chem., 265(27):16635-16643, (1990). Sen et al., "Basic Science/Circulation: Myocardial Structure and Pathology-Hypertrophy", Circulation (Suppl. II), 80(4):II-616, (1989) (abstract 2445). Shubeita et al., "Endothelin Induction of Inositol Phospholipid Hydrolysis, Sarcomere Assembly, and Cardiac Gene Expression in Ventricular Myocytes", J. Biol. Chem., 265(33):20555-20562, (1990). Sil et al., "Myotrophin in Human Cardiomyopathic Heart", Circ. Res., 73(1):98-108, (1993). Sil et al., "Role of Myotrophic in Pathophysiology of Cardiac Hypertrophy in Spontaneously Hypertensive Rat (SHR)", Circulation, 88(4 part 2):I-613, (1993) (abstract 3299). Sil et al., "Purification of Myotrophin from Human Cardiomyopathic Heart", FASEB J. 5(5991):A1244, (1991) (abstract 5069). Simpson et al., "Myocyte Hypertrophy in Neonatal Rat Heart Cultures and Its Regulation by Serum and by Catecholamines", Cir. Res., 51(6):787-801, (1982). Simpson et al., "Differentiation of Rat Myoctyes in Single Cell Cultures with and without Proliferating Nonmyo…