Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5539083A · kind A · utility
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67Claims
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Key dates
| Filing date | Feb 23, 1994 |
| Grant date | Jul 23, 1996 |
| Priority date | — |
| Expiry date | Feb 23, 2014 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00729
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are method of making random libraries of peptide nucleic acids using the fully preformed monomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.