Patent · US Expired

Backbone modified oligonucleotide analogs and solid phase synthesis thereof

US5541307A · kind A · utility

550Cited by

6References

32Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Phillip Dan Cook · Carlsbad, US
Yogesh S. Sanghvi · Encinitas, US
François Morvan · Castelnau-le-Lez, FR

Key dates

Filing date	Dec 28, 1993
Grant date	Jul 30, 1996
Priority date	—
Expiry date	Dec 28, 2013

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/16
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds and methods for preparing oligonucleotide analogs are provided. In preferred embodiments, the methods involve solid-phase coupling of synthons bearing either 3'-electrophillic groups and 5'-nucleophilic groups or 5'-electrophillic groups and 3'-nucleophilic groups to form neutral, achiral oligomers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.