DNA ligands of thrombin
US5543293A · kind A · utility
105Cited by
3References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 1994 |
| Grant date | Aug 6, 1996 |
| Priority date | — |
| Expiry date | Mar 28, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/976
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are described for the identification of nucleic acid ligand solutions to thrombin. The present invention utilizes the SELEX (Systematic Evolution of Ligands for EXponential Enrichment) method for identfying and preparing DNA ligands to thrombin. Further included in the present invention are modified nucleotide sequences based on the sequences of the DNA ligands identified. The modified DNA ligands to thrombin exhibit increased in vivo stability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.