Muteins of human epidermal growth factor exhibiting enhanced binding at low PH
US5547935A · kind A · utility
17Cited by
11References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 2, 1994 |
| Grant date | Aug 20, 1996 |
| Priority date | — |
| Expiry date | Aug 2, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
EGF muteins in which the histidine at position 16 is replaced with a neutral or acidic amino acid exhibit activity at pHs lower than obtainable with wild type EGF.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.