Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5549974A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 23, 1994 |
| Grant date | Aug 27, 1996 |
| Priority date | — |
| Expiry date | Jun 23, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31678
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. Arrays of thiazolidinones, metathiazanones, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antihistaminic, or antimicrobial activity or use in the treatment of inflammation, hypertension, renal failure, congestive heart failure, uremia and other conditions can be prepared using this method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.