Non-Peptide peptidomimetics

US5552534A · kind A · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Ralph F. Hirschmann · La Cañada Flintridge, US
• Kyriacos C. Nicolaou · Philadelphia, US
• Sherrie Pietranico · Philadelphia, US
• T. R. Reisine · Philadelphia, US
• Joseph M. Salvino · Chester Springs, US
• Paul A. Sprengeler · San Diego, US
• Catherine D. Strader · Verona, US

Key dates

• Filing date: Oct 28, 1993
• Grant date: Sep 3, 1996
• Expiry date: Oct 28, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, or R.sub.5 comprises a functional group which is chemically similar to that found in the peptide of interest.