Methods for the detection of acid-labile subunit (ALS) of insulin-like growth factor binding protein complex
US5561046A · kind A · utility
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Key dates
| Filing date | Mar 14, 1994 |
| Grant date | Oct 1, 1996 |
| Priority date | — |
| Expiry date | Mar 14, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/255
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An acid-labile protein is described that, when incubated with the 53-Kd acid-stable protein occupied by IGF, converts it to a high molecular weight complex, corresponding to the in vivo form of IGF. This protein is called the acid-labile subunit (ALS) of IGF binding protein complex and is provided in biologically pure form. ALS is useful in treating wounds and promoting cellular growth. The nucleic acid encoding ALS, antibodies binding thereto, and fragments thereof are also disclosed.
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