Glycosylated prodrugs, their method of preparation and their uses

US5561119A · kind A · utility

Assignees

• Laboratoires Hoechst · FR
• Behringwerke A.G. · DE

Inventors

• Jean-Claude Jacquesy · Guéret, FR
• Jean-Pierre Gesson · Poitiers, FR
• Claude Monneret · Paris, FR
• Martine Mondon · Poitiers, FR
• Brigitte RENOUX · Poitiers, FR
• Jean-Claude Florent · Boulogne-Billancourt, FR
• Michel Koch · La Celle-Saint-Cloud, FR
• François Tillequin · Paris, FR
• Hans-Harald Sedlacek · Marburg, DE
• Manfred Gerken · Marburg, DE
• Cenek Kolar · Marburg, DE
• Gilbert GAUDEL · Paris, FR
• Klaus Bosslet · Marburg, DE
• J org Czech · Marburg, DE
• Dieter Hoffman · Marburg, DE
• Gerhard Seemann · Lahntal, DE
• Hans-Ulrich Schorlemmer · Marburg, DE
• Gerhard Dickneite · Marburg, DE

Key dates

• Filing date: May 27, 1994
• Grant date: Oct 1, 1996
• Expiry date: May 27, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I). ##STR1##