2',3'-dideoxy-2'-fluoro-purine nucleosides and methods for using same

US5565437A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Victor E. Marquez · Gaithersburg, US
• John S. Driscoll · Rockville, US
• Christopher K. Tseng · Burtonsville, US
• James A. Kelley · Silver Spring, US
• David G. Johns · Bethesda, US
• Hiroaki Mitsuya · Rockville, US

Key dates

• Filing date: Nov 10, 1992
• Grant date: Oct 15, 1996
• Expiry date: Nov 10, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods of treating a human infected with human immunodeficiency virus (HIV), such as a human with AIDS, with the purina nucleotides 2',3'-dideoxy-2'-beta-fluoroadenosine (FddA) and 2',3'-dideoxy-2'-beta-fluoroinosine (FddI) are disclosed. These nucleotides are stable in an acid environment and thus can be used for oral administration. Methods of inhibiting human immunodeficiency virus replication in a human T cell using these purina nucleotides are also disclosed.