Benzimidazoles and pharmaceutical compositions containing them

US5565469A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Gerhard Mihm · Biberach, DE
• Norbert Hauel · Schemmerhofen, DE
• Uwe Ries · Biberach an der Riß, DE
• Jacobus C. Antonius van Meel · Biberach an der Riß, DE
• Wolfgang Wienen · Äpfingen, DE
• Michael Entzeroth · Warthausen, DE

Key dates

• Filing date: Mar 13, 1995
• Grant date: Oct 15, 1996
• Expiry date: Mar 13, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Angiotensin-II inhibiting benzimidazoles, useful for the treatment of hypertension. Exemplary compounds are: PA0 (a) 4'-[(2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)- methyl]-2-(1,3-thiazolidin-2,4-dione-5-methylidinyl)-biphenyl, PA0 (b) 4'-[(2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)- methyl]-2-sulpho-biphenyl, PA0 (c) 4'-[(2-ethyl-4-methyl-6-(5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl)-be nzimidazol-1-yl)-methyl]-2-sulpho-biphenyl, PA0 (d) 4'-[(2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)- methyl]-2-trifluoroacetylamino-biphenyl, PA0 (e) 4'-[(2-ethyl-4-methyl-6-(5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl)-be nzimidazol-1-yl)-methyl]-2-trifluoroacetylamino-biphenyl, PA0 (f) 4'-[(2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)- methyl]-2-(4-methoxy-benzylaminocarbonylaminosulphonyl)-biphenyl, PA0 (g) 4'-[(2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)- methyl]-2-(cyclohexylamino-carbonylaminosulphonyl)-biphenyl, PA0 (h) 4'-[(2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)- methyl]-2-(benzoylamino-sulphonyl)-biphenyl, PA0 (i) 4'-[(2-ethyl-4…