Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues
US5565555A · kind A · utility
217Cited by
7References
10Claims
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Key dates
| Filing date | Feb 21, 1995 |
| Grant date | Oct 15, 1996 |
| Priority date | — |
| Expiry date | Feb 21, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides, The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnostic uses, A method for making the hydrogen-phosphonodithioates is provided as well as a method for converting same to an activated intermediate for substitution on the phosphorus atom.
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