Molecular clones of HIV-1 viral strains MH-ST1 and BA-L, and uses thereof

US5576000A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Marvin S. Reitz, Jr. · Derwood, US
• Genoveffa Franchini · Washington, US
• Phillip Markham · Rockville, US
• Robert C. Gallo · Bethesda, US
• Franco Lori · Bethesda, US
• Mikulas Popovic · Bethesda, US
• Suzanne Gartner · Potomac, US

Key dates

• Filing date: Feb 15, 1995
• Grant date: Nov 19, 1996
• Expiry date: Feb 15, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/974
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST 1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.