Vectors with pectate lyase signal sequence
US5576195A · kind A · utility
69Cited by
3References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 9, 1994 |
| Grant date | Nov 19, 1996 |
| Priority date | — |
| Expiry date | Dec 9, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to DNA coding for a pectate lyase signal peptide which has been inserted into plasmids to create secretion vectors which are capable of producing a chosen protein by directing transport across the bacterial membrane. The secretion vectors have been used to secrete extracellular thaumatin and extracellular antibody fragments. The proteins produced by these vectors have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.