Indole derivatives as dopamine D.sub.4 antagonists
US5576336A · kind A · utility
7Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 13, 1995 |
| Grant date | Nov 19, 1996 |
| Priority date | — |
| Expiry date | Sep 13, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula (I), or a salt or prodrug thereof, wherein R represent hydrogen or C.sub.1-6 alkyl; Q represents a moiety of formula Qa or Qb; they are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D.sub.4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.