Dimeric arylisoquinoline alkaloid compounds

US5578729A · kind A · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• The Trustees of Boston College · US

Inventors

• Gerhard Bringmann · Würzburg, DE
• Michael R. Boyd · Mobile, US
• Roland G otz · Würzburg, DE
• T. Ross Kelly · Watertown, US

Key dates

• Filing date: Dec 23, 1994
• Grant date: Nov 26, 1996
• Expiry date: Dec 23, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a method of preparing dimeric arylisoquinoline alkaloids by coupling two isoquinoline building blocks, each of which may be the same or different, together with a symmetrical or nonsymmetrical biaryl building block to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric arylisoquinoline compounds and derivatives thereof.