Guanidine derivatives

US5583133A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Jean Ackermann · Riehen, CH
• David Banner · Basel, CH
• Klaus Gubernator · Glückstadt, DE
• Paul Hadvary · Biel-Benken, CH
• Kurt Hilpert · Therwil, CH
• Klaus-Helmut M uller · Bocholt, DE
• Ludvik Labler · Bottmingen, CH
• G erard Schmid · Kienberg, CH
• Thomas B. Tschopp · Ettingen, CH
• Hans Peter Wessel · Heitersheim, DE
• Beat Wirz · Basel, CH

Key dates

• Filing date: Aug 4, 1995
• Grant date: Dec 10, 1996
• Expiry date: Aug 4, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.