Azepanes and their ring homologues having protein kinase inhibiting activity

US5583222A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Pierre Barbier · Rixheim, FR
• Isabelle Huber · Geneva, CH
• Fernand Schneider · Basel, CH
• Josef Stadlwieser · Konstanz, DE
• Sven Taylor · Riedisheim, FR

Key dates

• Filing date: Jan 4, 1995
• Grant date: Dec 10, 1996
• Expiry date: Jan 4, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds of formula I ##STR1## wherein R.sup.1 -R.sup.9, R.sup.15, A, X, Y, Z and n have the meaning given in the specification are active as protein kinase inhibitors and can be used as medicaments, particularly for the treatment of inflammatory skin disorders and alopecia.